USS Sampson (DDG 102) was laid down 20 March 2005, launched 16 September 2006 and commissioned in Boston, Massachusetts on 3 November 2007 with Cmdr. Philip Roos as the commanding officer. San Diego was assigned as the Sampson’s homeport.
In July 2009 USS Sampson departed Naval Base San Diego with USS Nimitz (CVN 68) Carrier Strike Group for its maiden deployment.
In March 2010 USS Sampson returned to home after an eight-month underway period in support of maritime security operations in the U.S. 5th and 7th Fleet Areas of Responsibility. In June USS Sampson arrived in Portland, Ore., to celebrate the 103rd annual Portland Rose Festival. June 24 the Samson participated in Exercise Rim of the Pacific (RIMPAC) 2010.
In August 2011 USS Sampson pulled into South Harbor in Seattle, Wash., to participate in Seattle's Seafair celebration. In September USS Sampson dispatched an inflatable boat and swimmers to retrieve about 60 bales of assorted drugs from the ocean after the small boat dumped them overboard. After that the ship participated in USS Abraham Lincoln (CVN 72) Composite Training Unit Exercise (COMPTUEX), in preparation for an independent deployment.
In February 2012 USS Sampson departed San Diego for a scheduled deployment to the western Pacific and Middle East. In July USS Sampson participated in at-sea phase of Cooperation Afloat Readiness and Training (CARAT) Singapore.